Choose the word or phrase among A, B, C or D that best fits the blank place in the passage

Choose the word or phrase among A, B, C or D that best fits the blank pace in the passage: Louis Braille was born in 1809 (46)______Coupvray. He was a French teacher of the blind. He himself was blind from the age of three, and in 1818 he (47)______to the National Institute for the Young Blind in Paris. Soon showing marked ability in both (48)______and music, he became famous in Paris as an organist and violoncellist. In 1826 Braille began (49)______the blind in the institute. Braille is known for his idea of modifying the Barbier “point writing” system, used for coded army messages, to enable the blind to read. Point writing (50)______ of embossed dots and dashes on cardboard; the Braille system derived from it is used successfully today, in slightly modified form, and in many countries.
46. A. on B. at C. in D. of
47. A. has gone B. goes C. went D. was going
48. A. science B. scientist C. scientific D. scientists
49. A. to teaching B. teaching C. teaches D. taught
50. A. contains B. combines C. consists D. comprises