Although he is old, he runs every morning.
Despite..........being old, he runs every morning.
2. She was too tired to get up this morning.
She was so  tired that she couldn't get up this morning.
3. They have never seen such beautiful pictures.
These are............the most beautiful pictures they have ever seen.
4.In spite of having a headache, she still went to the meeting.
Although........ she had a headache, she still went to the meeting.
5. I have not met them since they moved to the countryside.
I last......met them when they moved to the countryside.......