1. Despite of=> 0 the film's amazing effects, its plot is not so appealing

2. However=> Though she doesn't look very beautiful, she has a kind heart

3. In spite=> Despite the fact that I don't like her way of talking, I appreciate her effoct

4. My brother isn’t very young, nevertheless, he talks like a middle-aged woman.
⇒ My brother isn’t very young, therefore, he talks like a middle-aged woman.
5. Although the fact that Mary’s recently moved to this city, she is so familiar with it.
⇒Despite the fact that Mary’s recently moved to this city, she is so familiar with it.
6. I often eat fast food. It is not, however, good for my health.
⇒ I often eat fast food. However, it is not, good for my health.
7. My brother wants to travel around the world. Although he can’t afford it.
⇒ My brother wants to travel around the world. But he can’t afford it.
8. I try to spare some time for my children. I am very busy, although.
⇒ I try to spare some time for my children. I am very busy, though