1.It was a comedy. Almost audience fell asleep. (although)

⇒Although it was a comedy almost audience fell asleep.

 2 The film was made twenty years ago. Many people have enjoyed seeing it. (however) .

⇒The film was made twenty years ago however many people have enjoyed seeing it.

3. We live in the same street. We rarely see each other. (in spite of) .

⇒  In spite of living in the same street, we rarely see each other.

4. This is his first role. His acting is excellent. (nevertheless) .

⇒I’ve been too busy to answer by email,nevertheless, I’ll do it soon.

5. Mary was sick. She didn’t leave the meeting until it ended (despite) 

⇒ Despite the sickness of Marry,she didn't leave the meeting until it ended