Here are the completed sentences using "though," "although," "in spite of," or "despite":

1. **Although** having a lot of money, they are not happy.
2. He passed the exam **despite** not studying the lesson.
3. **Although** she works with her sister, she calls her every night.
4. **Although** me and my brother live in the same house, we rarely see each other.
5. **In spite of** his sickness, he still goes to school.
6. **Although** it was cold outside, we went for a picnic.
7. My father is very strong **although** he is old.
8. We still go **despite** the bad weather.
9. **Although** we warned Ben many times, he still got lost.
10. I won’t stay here for a long time **although** I like it very much.
11. Nancy forgot her passport **despite** writing it in her to-do list.
12. It looks very near **although** it’s quite a long way away.
13. We slept well last night **despite** the noise.
14. **Despite** the cold weather, she didn’t wear a warm coat.
15. A lot of things went wrong **despite** our careful plans.