To solve the equation, we can start by simplifying the expression on the left side:

159 - (215 - x) = 5^2 * 2^2

First, let's simplify the exponentiation:

159 - (215 - x) = 25 * 4

Next, let's simplify the multiplication:

159 - (215 - x) = 100

Now, let's simplify the subtraction:

159 - 215 + x = 100

Combine like terms:

x - 56 = 100

Add 56 to both sides:

x = 156

Therefore, the solution to the equation is x = 156.