To solve the expression \(57 \times 25 + 43 \times 25 - 57 \times 21 - 43 \times 21\), we can use the distributive property to simplify the calculation.

First, let's rewrite the expression by factoring out common terms:

\[
57 \times 25 + 43 \times 25 - 57 \times 21 - 43 \times 21
\]

Group the terms with common factors:

\[
(57 \times 25 - 57 \times 21) + (43 \times 25 - 43 \times 21)
\]

Factor out the common factors in each group:

\[
57 \times (25 - 21) + 43 \times (25 - 21)
\]

Simplify the expressions inside the parentheses:

\[
25 - 21 = 4
\]

So the expression becomes:

\[
57 \times 4 + 43 \times 4
\]

Factor out the common factor of 4:

\[
(57 + 43) \times 4
\]

Add the numbers inside the parentheses:

\[
57 + 43 = 100
\]

So the expression simplifies to:

\[
100 \times 4 = 400
\]

Therefore, the value of the expression is:

\[
400
\]