Here are the words with underlined parts that differ in pronunciation:

1. **D. region** - The 'g' in "region" is pronounced as /dʒ/, while the 'g' in "depend," "relation," and "gender" is pronounced as /g/.

2. **A. area** - The 'a' in "area" is pronounced as /ɛ/, while the vowels in "lunar," "parade," and "water" involve different vowel sounds.

3. **C. opening** - The 'o' in "opening" is pronounced as /oʊ/, while the 'o' in "propose," "promote," and "working" are pronounced differently (with varying vowel sounds).

4. **D. skill** - The 'i' in "skill" is pronounced as /ɪ/, while the 'i' in "qualified," "issue," and "right" have different vowel sounds or pronunciations.

5. **D. scare** - The 's' in "scare" is pronounced with a different vowel sound /ɛə/ compared to the 's' pronounced in "propose," "present," and "represent" which are more like /ɛ/ or /ɪ/.

Hence:
1. D
2. A
3. C
4. D
5. D